FOR RESEARCH USE ONLY
IGF-1 LR3

CHEMICAL PROPERTIES

CAS NUMBER946870-92-4
MOLECULAR WEIGHT9117.60 g/mol
MOLECULAR FORMULAC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

PHYSICAL PROPERTIES

APPEARANCEWhite lyophilized powder in sealed borosilicate glass vial.
SEQUENCEArg-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn

IGF-1 LR3

IGF-1 LR3 is a long-acting synthetic analogue of Insulin-like Growth Factor 1 with an arginine substitution at position 3. Studied for its extended half-life and potent anabolic signalling properties.

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LOT NUMBERLMO-0626-IGF-020
REPORT NO.RPT-20018
HPLC PURITY98.50%

7× Independently Tested

HPLC PurityIndependent lab
IdentitySequence confirmed
Net ContentExact mg verified
SterilityContamination-free
EndotoxinsLAL tested
Heavy MetalsICP-MS screened
Batch ConsistencyLot-to-lot stability
TESTED

RESEARCH USE ONLY

This compound is sold strictly for in vitro research and laboratory use. Not for human or animal consumption. Not a drug, food, or supplement. By purchasing you confirm you are a qualified researcher and will use this compound in compliance with all applicable laws. Must be 21 or older.

RESEARCH

Long R3 Insulin-Like Growth Factor-I (IGF-I) Infusion Stimulates Organ Growth But Reduces Plasma IGF-I, IGF-II and IGF Binding Protein Concentrations
Conlon MA, Tomas FM, Owens PC, et al. · Journal of Endocrinology · 1995
Demonstrates Long R3 IGF-1 infusion stimulates organ growth in the guinea pig model while paradoxically reducing circulating native IGF-1 and IGFBP concentrations, confirming reduced binding protein sequestration.
PMID 7561636
Long [R3] Insulin-Like Growth Factor-I Reduces Growth, Plasma Growth Hormone, IGF Binding Protein-3 and Endogenous IGF-I Concentrations in Pigs
Dunaiski V, Belford DA. · Journal of Endocrinology · 1997
In vivo large animal study characterising the systemic effects of Long R3 IGF-1 administration on the endogenous GH/IGF-1 axis and IGF binding protein regulation.
PMID 9488001
Insulin-Like Growth Factor-I (IGF-I) and Especially IGF-I Variants Are Anabolic in Dexamethasone-Treated Rats
Tomas FM, Knowles SE, Owens PC, et al. · Biochemical Journal · 1992
Foundational study describing the Long R3 IGF-1 analogue and documenting its dramatically reduced IGFBP binding affinity compared to native IGF-1, establishing the pharmacokinetic rationale for the LR3 modification.
PMID 1371669

LAB RESULTS

LOT LMO-0626-IGF-020 · CURRENT

Certificate of Analysis

PURITY
98.50%
CAS
946870-92-4
MW
9117.60 g/mol
APPEARANCE
White lyophilized powder in sealed borosilicate glass vial.
VERIFIED

Third-Party Report

TESTING LABIndependent Analytics LLC
TEST DATEJanuary 2025
METHODS USED
HPLCMSAAA
RESEARCH APPLICATIONS

What the literature covers.

  • Extended half-life analogue studied for sustained IGF-1 receptor activation
  • Investigated for muscle satellite cell proliferation and differentiation
  • Evaluated for protein synthesis pathway upregulation in anabolic research
  • Long-Arg3 substitution studied for reduced IGFBP binding affinity

All compounds sold by Lumo are intended strictly for in vitro research and laboratory use only. These products are NOT intended for human consumption, medical, veterinary, or household use. By purchasing from Lumo, you acknowledge that you are a qualified researcher or institution and will use these products solely for research purposes in compliance with all applicable laws and regulations.

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